A measurement of the time it takes for a drug to lose half of its pharmacologic activity or half of its administered amount in the bloodstream or in its target tissues.
Hematopoietic Growth Factors
Protein hormones produced by the body to regulate blood development, affecting the production and maturation of blood-forming cells.
The process of screening a sample of compounds rapidly and in parallel, then analyzing the results and choosing further screening compounds based on this information.
Substances produced by one tissue and conveyed to another through the bloodstream, usually affecting growth or metabolism.
Monoclonal antibodies that have been synthesized by using recombinant DNA technology to avoid the clinical problem of an immune response to foreign substances. Humanized antibodies are produced by merging the DNA that encodes the binding portion of a monoclonal mouse antibody with human antibody-producing DNA. Cell cultures are used to express this recombinant DNA and produce these partial-mouse and mostly human antibodies.
The process of joining two complementary strands of DNA or one each of DNA and RNA to form a double-stranded molecule.
A cell that has been engineered to produce a desired antibody in large amounts. Hybridomas are created by fusing immortal tumor cells with antibody-producing B-lymphocyte cells that continuously synthesize identical (or monoclonal) antibodies.